Tacrolimus/Sirolimus (T/S)-Based GvHD Prophylaxis Does Not Overcome Poor Outcome of HLA Mismatch after Unrelated Donor (URD) Peripheral Blood Stem Cell Transplantation
نویسندگان
چکیده
منابع مشابه
NK-cell education is shaped by donor HLA genotype after unrelated allogeneic hematopoietic stem cell transplantation.
The rules governing natural killer (NK)-cell education in the allogeneic environment created by unrelated hematopoietic stem-cell transplantation (HSCT) are still largely elusive, especially in an unrelated donor setting. NK-cell inhibitory receptors for self-human leukocyte antigen (HLA) play a central role in the acquisition or maintenance of NK-cell functional competence. Therefore, the resp...
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Chronic graft-versus-host disease (GVHD) is a multisystemic syndrome involving tissue inflammation and fibrosis that shares many clinical manifestations with autoimmune diseases such as systemic lupus erythematous or systemic sclerosis. Despite being associated with lower relapse rates, chronic GVHD is the main cause of late mortality after unrelated allogeneic haemopoietic stem-cell transplant...
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B cells are implicated in the pathophysiology of chronic graft-vs-host disease (GVHD), and phase 2 trials suggest that B cell depletion can treat established chronic GVHD. We hypothesized that posttransplantation B cell depletion could prevent the occurrence of chronic GVHD. We performed a 65-patient phase 2 trial of rituximab (375 mg/m(2) IV), administered at 3, 6, 9, and 12 months after trans...
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HLA matching between donors and recipients is the most important factor associated with acute graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation. With improvements in GVHD prophylaxis and supportive care, transplantations from HLA mismatched donors are performed increasingly frequently, drawing greater attention to the effects of HLA mismatch. In relat...
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Anti-HLA donor-specific Abs (DSAs) have been reported to be associated with graft failure in mismatched hematopoietic stem cell transplantation; however, their role in the development of graft failure in matched unrelated donor (MUD) transplantation remains unclear. We hypothesize that DSAs against a mismatched HLA-DPB1 locus is associated with graft failure in this setting. The presence of ant...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2016
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2015.11.958